Computed Tomography (CT)

The following are ongoing research projects in collaboration with Marie Curie Research Wing, The Cancer Centre, Harefield Hospital, and University College Hospital:

Phase Ib trial of combretastatin in combination with radiotherapy in patients with advanced cancer of the lung, and head and neck
Phase I trial of LNNA in patients with cancer
Validation of volumetric perfusion CT with histopathology in lung cancer
Quantitative assessment of cardiac CT perfusion with integrated 82Rb-PET validation
Assessment of the metabolic flow relationship in primary colorectal cancer using intergrated Perfusion CT-PET/CT

Published papers (last 5 years; since 2002)

V Goh, J Liaw, CI Bartram, S Halligan
Effect of scan temporal interval on final colorectal vascular parameters: implications for helical perfusion CT
AJR Am J Roentgenology (In press)
V Goh, S Halligan, F Daley, T Guenther, D Wellsted, CI Bartram
Assessment of colorectal cancer vascularity by perfusion CT: Do perfusion measurements represent tumour angiogenesis?
Radiology (In press)
V Goh, S Halligan, D Wellsted, CI Bartram
Can perfusion CT assessment of primary colorectal adenocarcinoma blood flow at staging predict for subsequent metastatic disease? – Pilot Study.
European Radiology (In press)
A Groves, V Goh, S Rajasekaran, I Kayani, R Endozo, J Dickson, L Menezes, M Shastri, S Habib, P Ell, B Hutton
CT coronary angiography: Quantitative assessment of myocardial perfusion using test bolus data– initial experience
European Radiology 2008 May 9 Epub
V Goh, S Halligan, A Ghaupuray, CI Bartram
Quantitative assessment of tumor vascular parameters using MDCT: Influence of the tumor region of interest (ROI)
Radiology 2008;247:726-32
V Goh, AR Padhani, S Rasheed
Imaging colorectal tumour angiogenesis
Lancet Oncology 2007;.8: 245-255
V Goh, S Halligan, CI Bartram
Quantitative colorectal cancer perfusion assessment: Are measurements from different commercial software interchangeable?
Radiology 2007; 242: 777-82
QS Ng, V Goh, J Milner, MI Saunders, Padhani AR, PJ Hoskin
Tumor anti-vascular effects of radiotherapy combined with Combretastatin A4 Phosphate in human non-small cell lung cancer.
Int J Radiat Oncol Biol Phys 2007;67: 1375-80
V Goh, S Halligan, SA Taylor, D Burling, P Bassett, CI Bartram
Diverticulitis versus colorectal cancer: Are CT perfusion measurements better discriminators than morphological criteria.
Radiology 2007; 242: 456-62
QS Ng, V Goh, J Milner, GM Tozer, PJ Hoskin
Effect of nitric oxide synthesis on tumour blood volume and vascular activity in cancer patients: a phase I study
Lancet Oncology 2007; 8: 111-8
QS Ng, V Goh, J Milner, MI Saunders, Padhani AR, PJ Hoskin
Acute tumor vascular changes in lung cancer following fractionated radiotherapy: Quantitative assessment using volumetric perfusion CT.
Int J Radiat Oncol Biol Phys 2007; 67:417-424.
K Rothkamm, S Balroop, J Shekhdar, P Fernie, V Goh
Leukocyte DNA damage following MDCT: A quantitative biomarker of low level radiation exposure
Radiology 2007;242:244-251.
QS Ng, V Goh, E Klotz, H Fichte, P Fernie, M Saunders, P Hoskin, A Padhani
Quantitative assessment of lung cancer perfusion using MDCT: Does greater tumor volume coverage improve measurement reproducibiltiy
AJR Am J of Roentgenology 2006;187:1079-1084.
V Goh, S Halligan, L Gartner, P Bassett, CI Bartram
Quantitative assessment of colorectal cancer perfusion: Does increasing tumor coverage improve measurement reproducibility?
Br J Radiol 2006; 79:578-583.
V Goh, S Halligan, JA Hugill, CI Bartram
Quantitative assessment of colorectal cancer perfusion using dynamic contrast enhanced MDCT: reproducibility and comparison with normal muscle perfusion
AJR Am J of Roentgenology 2006; 187:164-169.
QS Ng, V Goh, E Klotz, H Fichte, P Fernie, M Saunders, P Hoskin, A Padhani
Qunatitative assessment of lung cancer perfusion using MDCT: reproducibility of a whole tumor analysis technique
Radiology 2006; 239:547-553.
SA Taylor, S Halligan, A Slater, V Goh, D Burling, M Roddie, J Demeshki
Polyp detection with CT colonography: comparison of a primary 3D endoluminal analysis with primary 2D axial read supplemented by computer assisted reader software.
Radiology 2006; 239:759-767
V Goh, AR Padhani
Imaging tumour angiogenesis: functional MDCT or MRI?
Abdominal Imaging 2006; 3: 194-199
V Goh, S Halligan JM Anderson, JA Hugill, A Leonard
Is direct radiologist supervision of abdominal computed tomography (CT) scans necessary?
Clinical Radiology 2005;60:758-761
V Goh , S Halligan, JA Hugill, CI Bartram
Quantitative colorectal cancer perfusion measurements using MDCT: inter and intra-observer agreement
American Journal of Roentogenology 2005; 185:225-231
V Goh, S Halligan, JA Hugill, L Gartner, CI Bartram
Colorectal cancer perfusion measurement using dynamic contrast enhanced MDCT: effect of acquisition time and implications for protocols
J Comput Assist Tomogr 2005;21:4881-4885
V Goh, S Halligan, CI Bartram
Local radiological staging of rectal cancer
Clinical Radiology 2004; 59:215-226
A Chambers, S Halligan, V Goh, S Dhillon, A Hassan
Therapeutic impact of abdomino-pelvic CT in patients with acute abdominal pain
Acta Radiologica 2004; 45:248-53
SA Taylor, S Halligan, V Goh, S Morley, P Bassett, W Atkin, CI Bartram
Optimising colonic distension for multidetector row CT colonography: effect of hyoscine butylbromide and rectal balloon catheter.
Radiology 2003; 229:109-118
SA Taylor, S Halligan, V Goh, S Morley, W Atkin, CI Bartram
Optimising bowel preparation for multidetector row CT colonography: effect of citramag and picolax.
Clinical Radiology 2003; 58:723-32.

Research presentations at international conferences

QS Ng, V Goh, J Milner, MR Stratford, L Folkes, GM Tozer, MI Saunders, PJ Hoskin
Nitric oxide synthase (NOS) inhibition in cancer patients: cardiovascular effects and relationship to pharmacokinetic and tumor blood volume measurements
Poster Presentation, ESMO, Stockholm, Sweden, 2008
A Groves, V Goh, M Rodriguez-Justo, A Engeldow, I Kayani, SA Taylor, R Cohen, S Halligan. P Ell
Assessment of the metabolic-perfusion relationship in primary colorectal adenocarcinoma using integrated 18- FDG PET/CT and perfusion CT
Oral presentation, SNM, New Orleans, USA, 2008
J Liaw, V Goh, D Wellsted, S Halligan
Influence of temporal resolution on tumour Perfusion CT measurements: implications for helical Perfusion CT techniques
Oral presentation, ESGAR, Instanbul, Turkey, 2008
J Liaw, F Gollub, R Glynne-Jones, V Goh
Assessment of the MRI appearances and pattern of distribution of pelvic lymph nodes in anal cancer.
Oral presentation, ESGAR, Instanbul, Turkey, 2008
A Gaya, NJ Taylor, JJ Striling, G Rustin, AR Padhani, V Goh
Early & Late Tumour Vasculature Changes Following the Vascular Disruptive Agent (VDA) Combretastatin-A4-Phosphate (CA4P) Using Dynamic Contrast Enhanced MRI (DCE-MRI) and Perfusion CT
Oral presentation, ESGAR, Instanbul, Turkey, 2008
HC Mandeville, V Goh, QS Ng, J Milner, MI Saunders, PJ Hoskin
Volumetric perfusion CT assessment of concurrent Combretastatin A4 phosphate and radiotherapy in non small cell lung cancer
ASCO, Chicago, USA, 2008
A Groves, V Goh, S Rajasekharan, I Kayani, R Endozo, J Dickson, L Menezes, M Shastri, P Ell, B Hutton
Coronary CT angiography: quantitative assessment of myocardial perfusion using test bolus data- initial experience
Oral presentation, ECR, Vienna, Austria, 2008
J Liaw, A Nikapota,R Glynne-Jones,V Goh
Radiotherapy for rectal cancer: role of imaging
Poster presentation, ECR, Vienna, Austria, 2008
V Goh, L Gartner, D Wellsted, CI Bartram, S Halligan
Perfusion CT of colorectal cancer: prediction of survival
Oral presentation, RSNA, Chicago, USA, 2007
QS Ng, V Goh, J Milner, MI Saunders, PJ Hoskin
The effects of tumor volume coverage on the assessment of vascular activity following radiotherapy in human non-small cell lung cancer
Poster presentation, ECCO, Cyprus, 2007
Groves AM, Kayani I, Dickson JC, Menezes LJ, Habib S, Prvulovich E, Ben Haim S, Bomanji JB, Hutton BF, Goh V, Ell PJ
Cardiac 82Rubidium PET/64 detector CT Angiography
Oral presentation, EANM, Copenhagen, Denmark, 2007
S Rajasekharan, B Hutton, A Groves, V Goh, J Dickson, M Shastry, L Menezes, R Endozo, P Ell
Potential to normalise myocardial perfusion SPECT using CT: technical considerations
Poster presentation, EANM, Copenhagen, Denmark, 2007
V Goh, F Gollub, AR Padhani, S Mawdsley, R Glynne-Jones
MR imaging of anal cancer: morphological features do not predict for clinical outcome
Oral presentation, ESGAR, Crete, 2007
V Goh, B Sanghera
Colorectal cancer perfusion: Tumor perfusion demonstrates fractal properties
Oral presentation, ESGAR, Lisbon, Portugal, 2007
V Goh, QS Ng, H Mandeville, E Klotz, H Fichte, J Milner, N Fry, MI Saunders, P Hoskin
Monitoring therapy in lung cancer: whole tumor assessment at perfusion CT improved on single level assessment
Oral presentation, ECR, Vienna, Austria, 2007
V Goh, A Gharpuray, S Halligan, CI Bartram
Quantitative assessment of colorectal perfusion: Influence of the tumor region of interest (ROI)
Oral presentation, RSNA, Chicago, USA, 2006
V Goh, S Halligan, F Daley, T Guenther, L Gartner, CI Bartram
Colorectal cancer perfusion measurments: Do quantitative measurements reflect angiogenesis or established vasculature?
Oral presentation, RSNA, Chicago, USA, 2006
V Goh, S Halligan, F Daley, T Guenther, L Gartner, CI Bartram
Colorectal cancer perfusion measurements: Do quantitative measurements correlate with measures of angiogenesis?
Oral presentation, ESGAR, Crete, Greece, 2006
V Goh, S Halligan, CI Bartram
Quantitative colorectal cancer perfusion assessment: do different mathematical analysis methods affect measurements?
Oral presentation, ECR, Vienna, Austria, 2006
V Goh, QS Ng, E Klotz, H Fichte, M Saunders, PJ Hoskin, AR Padhani
Quantitative whole tumour perfusion assessment using MDCT: reproducibility and observer variability in advanced lung cancer
Oral presentation, ECR, Vienna, Austria, 2006
V Goh, S Halligan, T Guenther, L Gartner, JA Hugill, CI Bartram
CT assessment of colorectal cancer perfusion:does tumor vascularity predict metastatic disease?
Oral presentation, RSNA, Chicago, USA, 2005
V Goh, S Halligan, SA Taylor, D Burling, L Gartner, CI Bartram
Differentiation of diverticular disease from colorectal cancer: are CT perfusion measurments of additional benefit to morphological criteria
Oral presentation, RSNA, Chicago, USA, 2005
QS Ng, V Goh, PJ Hoskin
Weekly CA4P in combination with radiotherapy: tumour antovascular effects as demonstrated using perfusion CT
Poster presentation, ECCO, Paris, France, 20055
QS Ng, V Goh, PJ Hoskin
Tumour antivascular effects of radiotherapy in lung cancer measured using quantitative whole tumour perfusion CT
Oral presentation, ECCO, Paris, France, 2005
V Goh, S Halligan, L Gartner, JA Hugill, C Bartram
Quantitative assessment of colorectal cancer perfusion using dynamic contrast enhanced MDCT: does multislice analysis improve measurement reproducibility?
EPOS presentation, ESGAR, Florence, Italy, 2005
N Wakeham, V Goh, R Chambers, W Wong
Staging of oesophageal cancer with intergrated PET-CT versus PET with diagnostic CT and diagnostic CT alone.
Oral presentation, ESGAR, Florence, Italy, 2005
SA Taylor, S Halligan, V Goh, A Slater, D Burling, M Roddie, J Demeshki
Polyp detection with CT colonography: comparison of a primary 3D endoluminal analysis with primary 2D axial read supplemented by computer assisted reader software.
Oral presentation, ESGAR, Florence, Italy, 2005
V Goh, QS Ng, D Carnell, H Fichte, E Klotz, P Fernie, M Saunders, PJ Hoskin, AR Padhani
Quantitative whole tumour perfusion measurement using MDCT: acute radiotherapy effects in lung cancer
Oral presentation at ARRS, New Orleans, USA, 2005
V Goh, QS Ng, D Carnell, H Fichte, E Klotz, P Fernie, M Saunders, PJ Hoskin, AR Padhani
Quantitative measurement of lung cancer perfusion using MDCT: does whole tumour analysis improve measurement variability?
Oral presentation at ARRS, New Orleans, USA, 2005
QS Ng, V Goh, Carnell D, Fichte H, Klotz E, Fernie P, Saunders M, Hoskin PJ, Padhani AR
Single versus three-level tumour perfusion measurement using helical dynamic contrast enhanced MDCT: effect on measurement agreement and potential for whole tumour assessment
Poster presentation ECR, Vienna, Austria, 2005
QS Ng, V Goh, D Carnell, H Fichte H, E Klotz, P Fernie, M Saunders, PJ Hoskin, AR Padhani
Quantitative multi-planar lung cancer perfusion measurement using multidetector row computed tomography (MDCT): inter and intra-observer agreement
Poster presentation ECR, Vienna, Austria, 2005
V Goh, S Halligan, JA Hugill, CI Bartram
Quantitative Colorectal Cancer Perfusion Measurement using Dynamic Contrast Enhanced Multidetector Row Computed Tomography: Effect of Acquisition Time and Implications for Protocols
Oral presentation ECR, Vienna, Austria, 2005
V Goh, S Halligan, JA Hugill, CI Bartram
Colorectal Cancer Perfusion Measurement with Multi-detector Computed Tomography: Measurement Reproducibility and Clinical Implications
Oral presentation, RSNA , Chicago, USA, 2004
Ng QS, Goh V, Hoskin PJ, Carnell D, Meer K, Padhani A
Tumour antivascular effects of combretastatin A4 phosphate(CA4P) in combination with radiotherapy measured using dynamic contrast enhanced computed tomography (DCE-CT)
Poster presentatation, ESTRO, Amsterdam, The Netherlands, 2004
V Goh, S Halligan, JA Hugill, JM Anderson, CI Bartram
Inter and intra-observer agreement in CT perfusion imaging of colorectal cancer
Oral presentation, RSNA, Chicago, USA, 2003